CYNAERA Institute
Predictive Research. Precision Frameworks. Systemic Repair.
The CYNAERA Institute is a systems intelligence research hub pioneering AI-powered models for a variety of areas. Including, but not limited to infection-associated chronic conditions (IACCs), such as PASC, ME/CFS, POTS, MCAS, and post-vaccine syndromes.
We build adaptive frameworks to map flare risk, stratify patients by remission potential, and power decentralized clinical trial design. This is research for those who’ve been ignored , and tools for the systems that failed them.
AI-guided Research Publications
Whether you're new to research or ready to publish full-length clinical trials, the CYNAERA Research Institute offers two FREE powerful AI tools designed to match your level of expertise. NeuroSearching-GPT™ is ideal for beginners, patient advocates, and first-time researchers, it walks you step-by-step through building an infection-associated chronic conditions (IACCs) research question, selecting the right format, and generating a complete policy brief, report, or introduction to publication-ready work.
If you’re more advanced, the IACC Clinical Trials Simulator GPT™ is built for citizen scientists, expert advocates, and research professionals who want to run trial simulations, model patient trajectories, or produce formatted journal submissions using CYNAERA’s full suite of publicly available predictive modules. Both tools help turn real-world insight into real-world impact, no fees, gatekeeping, or permission required.
CYNAERA Institute at a Glance
Remission, Simulated at Scale
Over 675 million synthetic patient journeys modeled using CYNAERA’s terrain-based intelligence. Each simulation maps flare progression, stabilization phases, and remission probability across multi-system conditions, from immune collapse to autonomic rebalancing.
Our inaugural full-stack logic system, was bult for MECFS to formulate US and global prevalence, diagnostics, pediatrics, undercount of men, environmental impact, and AI-driven flare prediction to reshape how this condition is understood, diagnosed, and treated.
Conditions Modeled and Mapped
79+ chronic illnesses, including:
Post-infectious conditions like Long COVID, ME/CFS, and Chronic Lyme
Neuroimmune and hormonal syndromes including POTS, MCAS, CRPS, Fibromyalgia
Autoimmune and environmentally triggered illnesses
Cancer-prone terrain profiles emerging from multisystem dysregulation
Current portfolio includes:
15 infection-associated conditions (IACCs)
10+ neuroinflammatory/hormonal diagnoses
3 pre-cancer terrain trajectories
Global Impact Potential
Between 325–375 million people worldwide could benefit from CYNAERA’s remission mapping, flare prediction, and trial stratification tools. That includes patients who remain misdiagnosed, undercounted, or excluded from traditional clinical models.
Our Research Pillars
Predictive Simulation- Synthetic cohorts modeled to test remission logic, gene edit impact, and flare forecasting.
Terrain Intelligence - Quantitative mapping of systemic burden using multi-biomarker and symptom cluster inputs.
Remission Science - Frameworks for identifying, accelerating, and validating pathways to recovery.
Stratified Trial Design - AI-informed subgroup targeting for precision enrollment in real-world conditions.
Foundational Databases
Pediatric Chronic Illness Database - First national prevalence recalculation across 38 chronic conditions in children. Use Cases: IEP eligibility logic, school-based diagnosis gaps, pediatric trials.
Women’s Health Visibility Model - Applies hormone-phase adjustment, gendered diagnostic bias, and flare timing logic. Use Cases: Workforce loss, fertility links, diagnosis lag correction, postpartum risk.
Featured Frameworks
CRISPR Remission™- AI-simulated gene editing models for multisystem remission targeting
US-CCUC™: Corrects federal government prevalence estimates.
VitalGuard™- Environmental risk forecaster for air-quality–sensitive populations
SymCas™- Symptom sequencing engine to detect pre-flare instability in remitting conditions
PULSE™- Narrative-anchored modeling for detecting underreported medical trends
Research Publication Volunteers
To support the rapid expansion of CYNAERA’s research output, I am onboarding a select group of high-performing volunteers to assist with the preparation of publication-ready insights.
Volunteers who demonstrate consistency, discretion, and executional precision will be granted access to CYNAERA’s internal research tools. This includes AI-assisted trial simulation, policy modeling engines, and preprint automation systems. This access allows contributors to develop and publish independent novel insights, pursue co-authorship opportunities on institutional white papers, or propose new research threads aligned with CYNAERA’s current modeling infrastructure.
This is an opportunity to help shape real-world research at the intersection of AI, chronic illness, and diagnostic reform. Patients and caregivers highly encouraged to apply.