PRESS RELEASE

For Immediate Release

August 31st, 2025

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CYNAERA Unveils Unified Theory of ME/CFS and IACCIs Anchored in the Primary Chronic Trigger Model
 

Breakthrough developed in four months on minimal funding reframes chronic illness as predictable collapse.

 

Vienna, VA — August 31st, 2025 - CYNAERA today announced the Unified Theory of ME/CFS and Infection-Associated Chronic Conditions (IACCIs), a framework that explains how infections, environmental exposures, and medical events ignite chronic illness. Anchored in the Primary Chronic Trigger (PCT) Model, the Unified Theory reframes ME/CFS, Long COVID, POTS, MCAS, and related syndromes as predictable outcomes of terrain collapse rather than isolated mysteries.

 

A Primary Chronic Trigger is the initiating event, such as a viral infection, mold exposure, or surgery, that permanently alters how the body manages stress, repair, and inflammation. Once this threshold is crossed, patients often fail to return to baseline and may develop multiple overlapping conditions.

 

“The Unified Theory demonstrates that these illnesses are not rare or inexplicable. They are the body’s response to a destabilizing trigger,” said Cynthia Adinig, Founder of CYNAERA. “I created this not from an ivory tower but as a patient and caregiver charting my own recovery and my child’s. That perspective is why I could see patterns others missed and move quickly to build what billion-dollar companies could not.”

 

While firms like Palantir, Google Health, and IBM Watson Health have invested billions in healthcare AI without solving the riddle of chronic illness, CYNAERA achieved this Unified Theory in just four months on what can only be described as a shoestring budget. Big tech has focused on billing codes and hospital operations, while CYNAERA explains illness itself.

This work was also slated for federal review under the Office of Long COVID at HHS, where Adinig had agreed to contribute at no cost. That office was dissolved by executive order before its first meeting, delaying progress by years. CYNAERA has now advanced the Unified Theory independently, but the federal government’s missed opportunity represents billions in lost economic productivity and research value.

 

COVID-19 revealed the urgency. With tens of millions of Americans already living in post-viral terrain states, CYNAERA projects that 65 to 75 million are affected. The Unified Theory warns that a future pathogen with SARS-CoV-2 like properties could drive up to 30 percent of the U.S. population into chronic illness terrain collapse.

 

About CYNAERA

CYNAERA is a systems-intelligence  developing algorithms and predictive frameworks for chronic illness, climate, and systems resilience across 32 sectors. Founded by Cynthia Adinig, CYNAERA integrates AI, modeling, and patient-informed research to anticipate risks and design actionable solutions.

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Press Contact:
Email: cynthia@cynaera.com

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