Clinical Trial Simulator
Remission, simulated at scale.
Every failed trial represents a missed chance to bring relief, recovery, and remission. The CYNAERA Clinical Trial Simulator is designed to prevent that loss before it happens. It is the first terrain-based modeling system that merges immunology, autonomic stability, and environmental data into one decision intelligence platform.
Built from more than two hundred million synthetic patient journeys, the simulator reconstructs every stage of a clinical trial. It predicts efficacy, safety, dropout rates, and equity impact before recruitment even begins. For universities, hospitals, and early-stage biotech companies, this means less wasted time, lower cost per protocol, and more confidence when moving from concept to patient outcome.
Clinical Trial GPT — Free Educational Access
Researchers and students can explore a simplified version of CYNAERA’s engine through the public-interest model called Clinical Trial GPT. This interactive tool allows users to design small trial concepts, test different endpoints, and see how demographic diversity influences outcomes.
The public version uses generative reasoning based on real-world trial data and publicly available literature. It does not contain proprietary formulas, but it offers an authentic sense of how terrain-based logic changes the way a study is designed.
Perfect for:
Graduate students in public health, medicine, and data science
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University research teams evaluating new trial frameworks
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Small labs experimenting with proof-of-concept modeling
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Clinical Trial GPT was created to make complex research design accessible and inspire the next generation of investigators who believe open access science is achievable.
Try it free! Outputs are simulated for educational demonstration only. Full-scale accuracy is reserved for licensed partners.
Institutional Partnerships
CYNAERA collaborates selectively with organizations that share its mission to modernize clinical research. The simulator is not an off-the-shelf tool; it is a secure analytical environment that aligns with NIH, FDA, and PCORI priorities on trial diversity and cost efficiency.
Typical partner categories include:
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University medical research centers
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Hospital innovation programs
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Small biotech and pharmaceutical startups
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Government research agencies and public-private consortia
Partnerships include technical integration, joint validation, and access to advisory sessions that help teams adapt existing protocols to the terrain-based framework. Every agreement is tailored to the institution’s research scope, ensuring data privacy and intellectual property protection.
Part of the CYNAERA Fast Track System™
The simulator anchors CYNAERA’s Fast Track Drug Repurposing and Terrain Intelligence programs. These systems work together to shorten the time between discovery and remission, guiding trial design that is faster, safer, and more representative of the real world.
See the Power in Motion
Our demonstration video offers a glimpse inside the real simulator used by our partners. In under three minutes, it shows how CYNAERA generates virtual cohorts, adjusts for genetic and environmental variability, and predicts both primary and secondary endpoints across time. Each frame is based on genuine modeling output from the proprietary engine that powers national-level research projects. You will see how terrain intelligence detects unseen risks, how remission curves evolve as the system learns, and how equity variables are built directly into the calculations.
Intellectual Property and Access Control
The full CYNAERA Clinical Trial Simulator is protected under proprietary data modeling and security protocols. Unauthorized replication, export, or use of derivative algorithms is prohibited under federal intellectual property law. Access is granted only to verified institutional partners following compliance review and signed confidentiality agreements.
Clinical Trial Simulator Pricing
While CYNAERA does not disclose exact licensing rates publicly, we are providing this information to guide exploratory conversations. Pricing varies by research scale, regulatory environment, and partnership status.
Starter
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Introductory access for academic or hospital teams studying trial simulation methods.
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Great for small research teams. Universities and teaching hospitals.
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Limited simulations, restricted dataset, standard advisory report.
Professional
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Intermediate package for multi-site trials or grant-funded projects.
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Early-stage biotech or academic research networks
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Moderate simulation volume, diversity weighting, technical consultation.
Enterprise
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Comprehensive license for government and industry partners .
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Great for conducting full protocol design and predictive modeling.
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CROs, public-private consortia, federal agencies.
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Large-scale simulations, dedicated advisory team, white-label integration.
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Actual pricing and licensing terms are available only under NDA.
CYNAERA does not offer public API or unrestricted user access.
System Capability Overview
The CYNAERA Clinical Trial Simulator is built to operate across most disease categories that involve immune, metabolic, or environmental interaction. The engine does not rely on a single diagnostic code or biomarker but instead interprets the body’s terrain as a living network of immune, vascular, and neurological feedback loops. This approach allows the simulator to work across hundreds of research domains while maintaining accuracy at population, biomarker, and outcome levels.
Fully Supported Domains
The CYNAERA Clinical Trial Simulator is built to operate across most disease categories that involve immune, metabolic, or environmental interaction. The engine does not rely on a single diagnostic code or biomarker but instead interprets the body’s terrain as a living network of immune, vascular, and neurological feedback loops. This approach allows the simulator to work across hundreds of research domains while maintaining accuracy at population, biomarker, and outcome levels.
Infection-Associated Chronic Conditions (IACC): Long COVID, ME/CFS, Chronic Lyme, Mast Cell Activation Syndrome, Postural Orthostatic Tachycardia Syndrome, and related post-viral syndromes.
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Neuroimmune and Autonomic Disorders: Fibromyalgia, CRPS, small fiber neuropathy, autonomic instability, and dysautonomia-driven inflammatory states.
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Hormone–Immune Axis Conditions: Menopause-related immune rebound, PCOS inflammatory phenotypes, testosterone and estrogen immune modulation studies.
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Oncology and Immune Collapse Pathways: Conditions modeled under CRATE™ for tumor microenvironment instability, cytokine persistence, and pre-cancer terrain prediction.
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Environmental and Climate-Linked Illnesses: Mold-related disease, wildfire smoke sensitivity, air pollution–induced autonomic flare risk, and water contamination studies through VitalGuard™ overlays.
Partially Supported Domains
Genetic or Structural Disorders:
Modeling available for secondary inflammatory and metabolic responses, though primary mutation behavior is outside the system’s scope.
Psychiatric and Cognitive Studies: Fully supported when linked to neuroimmune or post-viral pathology through NeuroVerse™; behavioral-only studies require external integration.
Acute Trauma or Surgical Models: Available through stabilization overlays such as STAIR™ and BST™, designed for pre- and post-intervention prediction.
Coverage Summary
The CYNAERA Clinical Trial Simulator covers a wide range of research domains that span infection-associated, neuroimmune, hormonal, oncologic, genetic, and environmental systems. Each category connects to specific CYNAERA modules, allowing either full or partial simulation depending on the complexity of the biological network being modeled.
Immune and Infectious Conditions
Fully supported through the Pathos™, SymCas™, and PULSE™ modules.
Used to predict remission and treatment response in trials for Long COVID, ME/CFS, Chronic Lyme, and other infection-associated conditions.
Neuroimmune and Autonomic Disorders
Fully supported through NeuroVerse™ and SymCas™.
Used to model autonomic drift, fatigue cycles, and flare progression across conditions such as POTS, CRPS, and fibromyalgia.
Hormone–Immune Axis Conditions
Fully supported through Pathos™ and VitalGuard™.
Used to assess immune modulation and inflammatory trends in menopause, PCOS, and hormone therapy cohorts.
Oncology and Immune Exhaustion
Fully supported through CRATE™ and Pathos™.
Used to simulate tumor microenvironment rebalancing, cytokine activity, and immune collapse pathways relevant to pre-cancer and immune-oncology studies.
Genetic and Structural Disorders
Partially supported through SymCas™ and VitalGuard™.
Used to analyze secondary inflammatory burden or metabolic instability following gene or cellular therapy.
Psychiatric and Cognitive Conditions
Partially supported through NeuroVerse™.
Used to examine neuroinflammatory fatigue and cognitive recovery trajectories in post-viral and neuroimmune contexts.
Acute or Surgical Scenarios
Partially supported through STAIR™ and BST™.
Used to forecast stabilization, post-event recovery, and longitudinal healing patterns after medical interventions.
Environmental and Climate-Linked Illnesses
Fully supported through VitalGuard™ and MoldX™.
Used to model flare probability, autonomic instability, and symptom clusters by region, air quality, and humidity level.
CYNAERA systems are continuously updated with new datasets and validated through collaborations with universities, research hospitals, and government partners to ensure accuracy, reproducibility, and equity in every model.