The Human Variable 

Autoimmune and immune-mediated illness rarely begins with a clear diagnosis. More often, it begins with patterns that repeat long before medicine assigns a label. Symptoms rise, fall, and cluster. Tests come back “normal.” Patients are told to wait, monitor, or manage symptoms. Yet the immune system is already behaving abnormally. This paper refers to that early, overlooked phase as Stage Zero autoimmune illness.

The Diagnostic Acceleration Blueprint™ modernizes IACC diagnostics by combining reuse-first biospecimen pipelines, digital consent, and ML-driven multi-system fingerprints. This framework cuts timelines by 95%, costs by 99%, and eliminates multi-year delays rooted in outdated systems.

CDF-POTS is a new AI powered diagnostic fingerprint that captures the hidden patterns of POTS across cognitive, cardiac, vascular, and orthostatic domains. An estimated 16.5M Americans are living with POTS, most without a formal diagnosis. This model removes diagnostic waste by 86 percent, cuts ER visits by 70 percent, and restores workforce participation while saving the United States up to 400B dollars annually.

The Antiviral Pairing Logic framework synthesizes longitudinal field analysis across more than two hundred patient trajectories with in silico terrain modeling and real-world pharmacology. Durable response consistently follows three preconditions: immune stabilization to prevent cytokine rebound, mast cell and autonomic modulation before viral clearance, and energy and vascular repair after antigen reduction.

CYNAERA REPURPOSED™ accelerates drug discovery for infection-associated chronic conditions like Long COVID and ME/CFS. Using AI-driven terrain modeling, it cuts repurposing timelines from years to weeks—identifying multi-indication therapies, reducing cost by up to 90%, and advancing patient-ready treatments through intelligent simulation.

When the full IACC population is included, the national total of adults likely experiencing medical sabotage, partner interference, or care-linked neglect rises to approximately 24 million. RAVYNS™ is the first integrated system to transform partner interference and institutional neglect in chronic-illness care into an auditable public-health metric.