AVERY™ Pediatric System
From “mystery illness” to health trajectories that can be prevented, and treated.
Children are not small adults. Their bodies, brains, immune systems, and environments are changing every month. AVERY™ is CYNAERA’s pediatric engine that treats childhood as a dynamic terrain, not a static diagnosis. It helps families, clinicians, schools, and public agencies understand which kids are vulnerable, what tips them into chronic illness, and which environments keep them stable over a lifetime.
Why Pediatric Terrain Intelligence Is Urgent
Children today are growing up in:
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Buildings with aging HVAC systems and hidden mold
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Regions with frequent wildfire smoke and rising PM2.5
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Classrooms that were never designed for post viral immune instability
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Households juggling chronic illness, caregiving, and economic stress
When a child “never recovers” after COVID, strep, or other immune hit, most systems treat it as:
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anxiety
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behavior
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school refusal
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puberty
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parenting
AVERY treats it as terrain.
The engine asks:
What changed in this child’s body
What changed in the environment
What needs to stabilize in order to protect their future
What AVERY Does
AVERY reconstructs the invisible timeline behind a child’s decline or fragility. It looks at the infections they’ve had, the buildings they spend time in, the air they breathe, the seasons that repeatedly trigger symptoms, the sleep regression patterns, and the developmental cues that were dismissed as “normal.” The system models what changed in the child’s body, what changed in their environment, and why those changes combined to create a chronic pattern instead of a typical recovery. It identifies the primary trigger, the amplifiers, and the current tipping points. It then simulates how that child’s future shifts under different conditions: improved air quality, reduced exertion, safer housing, recovery windows, targeted interventions, or simply a school year without repeated exposures. This is where pediatric digital twins come in. They allow families and clinicians to look at the child they love from multiple futures: the stable path, the volatile path, the path affected by that gym renovation’s dust, the path shaped by wildfire season. For the first time, anyone caring for the child can see what is actually at stake.
Pediatric Digital Twins as a Scientific Tool
AVERY uses digital twin logic designed specifically for children and teens.
Each pediatric twin represents a plausible year by year health path under different conditions:
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What happens if a child stays in a mold contaminated school for three more years
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How many flares can be avoided if air filtration is installed and pacing protocols are honored
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What changes if the family relocates from a wildfire corridor to a lower volatility region
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How much school attendance and cognitive performance can improve if the terrain is stabilized early
These twins are not science fiction avatars. They are practical scenario tools that help schools, clinics, and families choose the least harmful path.
What AVERY Can See
AVERY ingests longitudinal patterns, not just single visits. It can include:
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Past infections such as COVID, flu, strep, EBV, Lyme
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Environmental history such as mold exposure, wildfire smoke, AQI spikes, heat waves, floods, and dust-prone housing
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Symptom sequences such as fatigue, dizziness, pain, brain fog, GI trouble, airway sensitivity, sleep shifts, and mood changes
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School patterns such as attendance, performance, sudden decline, or “good days versus crash days”
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Family and social context such as caregiving load, barriers to rest, and access to safe housing
From those inputs, AVERY produces:
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Pediatric terrain fragility scores
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Trigger maps that show which events turned into primary chronic triggers
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Seasonal and environmental risk windows
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Predicted flare seasons and dangerous thresholds
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Early warning signals for long flu, Long COVID, dysautonomia, MCAS, and autoimmune syndromes
Algorithmic Determination of Pediatric Primary Chronic Triggers
A defining strength of AVERY is its ability to determine the primary chronic trigger, or PCT, behind a child’s long-term symptoms. It applies your PCT framework directly to pediatric biology, where timing, developmental stage, and environments interact in ways that traditional pediatrics rarely tracks.
Children who develop chronic illness after influenza, COVID, strep, mold exposure, RSV, adenovirus, tick-borne infections, wildfire smoke, or deteriorating building quality often show overlapping clinical patterns. Because these events frequently occur close together, standard medical evaluation cannot distinguish which exposure or infection pushed the system from recovery into chronicity.
AVERY reconstructs that sequence with precision. It examines when symptoms first appeared, how autonomic signals shifted, how immune volatility changed, and what endocrine phase the child was in during the destabilizing event. It folds in climate and air-quality conditions, the state of the home or school environment, the presence of mold or particulate load, and any prior pattern of symptom rebound. It also evaluates whether recovery windows were collapsing at the time of the triggering event. Taken together, this enables the system to identify whether the chronic trajectory was driven primarily by infection, environmental exposure, hormonal transition, autonomic fragility, or a combined cascade.
Optimizing Interventions and Avoiding Adverse Events
Once PCT and secondary amplifiers are identified, AVERY connects directly to other CYNAERA engines to guide safe, personalized intervention strategies.
SymCas monitors rebound and crash patterns. VitalGuard tracks environmental triggers in real time and assigns susceptibility windows. Stabilization Windowing alerts clinicians to optimal timing for treatment introduction. Pathos scores chronicity severity and progression. NeuroVerse maps neuroinflammatory load and cognitive drift. PULSE estimates underrecognized symptom clusters and diagnostic blind spots.
Together, these allow AVERY to predict:
• whether a child is safe to start a medication
• whether a therapy will provoke a flare
• whether environmental conditions create hidden organ stress
• whether school attendance patterns reflect physiologic instability
• whether a child’s symptoms are worsening because of climate events, infections, or endocrine shifts
• whether a developmental delay is biologic, environmental, or both
Why AVERY Changes the Public Health Landscape
AVERY is built to follow a child’s physiology over time rather than capturing a single diagnostic snapshot. CYNAERA systems are longitudinal, so the model could continue to track a child's terrain as they move through puberty, hormonal maturation, academic stress cycles, reinfections, environmental shifts, relocations, and developmental transitions. A child who tips into chronicity at nine often carries that vulnerability into adolescence and adulthood. AVERY identifies that trajectory early and gives families the ability to understand what environmental, infectious, or structural pressures heighten risk over the long arc of development. It supports decisions about school environments, housing quality, climate exposure, sports participation, vaccination timing, and the broader care plan that can influence whether symptoms stabilize or compound. The goal is simple but transformative: turn vulnerability into foresight, and foresight into prevention.
From a population-level perspective, AVERY enables an entirely new scale of pediatric insight. It provides the capacity to map chronic illness patterns across regions, identify how school building conditions contribute to localized clusters, and detect how climate volatility influences symptom flares in children with underlying autonomic or immune instability. It supports geographic detection of undiagnosed IACC concentrations and quantifies the health-economic burden that pediatric disability creates for states and federal systems. CYNAERA ecosystems can simulate policy interventions, agencies can evaluate the impact of school air-quality upgrades, improved ventilation standards, or targeted infectious-disease mitigation before implementation.
AVERY gives public health leaders the ability to see where pediatric risk is building long before those children enter emergency rooms or disability rolls. It is, in effect, the blueprint for the next twenty years of pediatric public health infrastructure.
