CYNAERA Achievements
This is a definitive record of what has been built, what has been proven, and what now exists because CYNAERA exists. This page consolidates every global first, national first, largest analytic system, and multi-sector accomplishment across women’s health, pediatrics, infection-associated conditions, environmental intelligence, oncology-linked terrain, and clinical trial reform. It is designed for partners, foundations, federal agencies, researchers, and the press who need a clear understanding of CYNAERA’s scale, impact, and operational footprint.
Global Firsts
First analytic ecosystem modeling more than 2,000 chronic illnesses
A unified architecture spanning infection-associated, autoimmune, endocrine, neurologic, pediatric, rural, environmental, and immune-oncology domains.
First quattuorvigintillion-scale analytic architecture in health, climate, and policy
CYNAERA is the first known system to exceed 10⁸⁰ non-redundant analytic pathways, integrating clinical, environmental, demographic, economic, and national-security modeling into one computational fabric.
First intelligence platform spanning 32 sectors under one architecture
A multi-domain system unifying health, climate, labor, rural infrastructure, pediatrics, women’s health, oncology terrain, emergency medicine, and economic modeling.
First multi-mechanism remission logic systems for ME/CFS and Long COVID
The only remission architecture integrating immune, autonomic, hormonal, neurologic, metabolic, and environmental signaling.
First chronic illness digital twin system at population scale
A multisystem synthetic-patient engine capable of hundreds of millions of trajectories, expandable toward one billion.
First patient-founded AI platform with more than 50 interoperable engines
A modular engine network that chains, replicates, and expands intelligence without hardware dependency.
First pediatric–women’s–post-infectious unified modeling ecosystem
DAWN™, AVERY™, and IACC modeling form the first end-to-end analytic system from puberty to pregnancy to postpartum to youth infectious-onset instability.
First integrated rural–pediatric–environmental chronic illness engine
A comprehensive system mapping rural infrastructure strain, pediatric immune instability, environmental drift, socioeconomic fragility, and multisystem illness trajectories.
First fungal-pandemic engine rooted in chronic illness vulnerability
A climate-biologic model connecting humidity drift, mold proliferation, immune dysregulation, and long-term post-viral terrain collapse.
First national-security chronic illness intelligence engine
A cross-disciplinary platform linking illness prevalence to force readiness, climate volatility, infrastructure fragility, and emergency operations.
First patient-led clinical trial stabilization intelligence system
A full architecture preventing trial failure in multisystem illness through mechanistic alignment and study-stabilization logic.
First immune-related cancer susceptibility engine linked to chronic illness biology
CRATE™ is the first system modeling immune depletion, viral sequelae, environmental stress, and chronic terrain as contributors to oncologic vulnerability.
First global pediatric-focused IACC modeling system
AVERY™ integrates pediatric immune drift, autonomic instability, PANS/PANDAS, MIS-C, youth dysautonomia, and developmental derailment.
First AI-assisted research and publication engine for multisystem illness
A computational layer generating publication-grade hypotheses, trial arms, environmental forecasts, diagnostic signals, and economic models.
Global Largest Systems
Largest analytic system in any health, climate, or public-policy domain
A computational ceiling exceeding 10⁸⁰ analytic pathways, surpassing epidemiology, genomics, and climate modeling.
Largest chronic illness intelligence architecture in the world
More than 1,000 core modules, tens of thousands of variants, and over 2,000 modeled conditions.
Largest chronic illness digital twin library
Hundreds of millions of synthetic trajectories, with expansion capability toward one billion.
Largest analytic ecosystem created by a patient-led institute
More than two billion adaptive modules internally generated.
Largest global prevalence correction architecture
CGPI™ spans 180 countries with gender, demographic, rural, cultural, and diagnostic-suppression adjustment.
Largest pediatric and women’s chronic illness modeling ecosystems
DAWN™ and AVERY™ build the most comprehensive immune–endocrine developmental architecture globally.
Largest rural-health computational model
Mapping environmental pressures, hospital-access collapse, agricultural drift, pediatric instability, and socioeconomic fragility at national scale.
Largest environmental-trigger chronic illness forecasting system
VitalGuard™ and its submodules (MoldX™, FIRE™, PMC™, Planet™) form the deepest environmental–health intelligence stack available.
Largest cross-condition module library
More than two billion adaptive modules supporting multidomain modeling.
Largest computational interface between chronic illness and oncology terrain
CRATE™ integrates immune drift, viral aftermath, chronic sequelae, and environmental stressors with oncologic risk modeling.
Largest patient-created chronic-care economic forecasting engine
Federal inefficiency modeling across HHS, CMS, VA, SSA, FEMA, DoD, and state-level systems.
United States Firsts
First patient-founded institute to model trillion-dollar federal savings
Cross-agency modeling covering SSA, CMS, VA, FEMA, HHS, and DoD.
First patient-built clinical trial optimization and stabilization engine
A study design, stratification, and mechanistic alignment suite operating independently of academia or industry.
First pediatric–women’s–IACC unified U.S. platform
DAWN™, AVERY™, and IACC together create the first national architecture spanning childhood through womanhood.
First diagnostic modernization blueprint for multisystem illness
Upgrading ER and urgent-care detection using existing infrastructure.
First climate–illness risk engine built outside federal agencies
A forecasting model connecting wildfire smoke, mold proliferation, barometric instability, HVAC failure, and climate-linked illness.
First system linking pediatrics, education, and environmental exposure
A national engine mapping cognitive drift, autonomic instability, absenteeism, and illness severity.
First cross-agency preparedness system developed outside government
A public–military model integrating environmental risk, infrastructure fragility, and health vulnerability.
United States Largest Systems
Largest patient-created chronic illness analytic ecosystem
The full CYNAERA architecture.
Largest women’s chronic illness system built outside NIH
DAWN™ models menstrual physiology, pregnancy, postpartum instability, perimenopause, menopause, and chronic terrain across hormonal arcs.
Largest pediatric post-infectious model in the United States
AVERY™ integrates PANS, MIS-C, youth dysautonomia, endocrine volatility, cognitive decline, and developmental derailment.
Largest socioeconomic-burden modeling system by a patient researcher
Mapping household collapse, income destabilization, federal inefficiency, generational drift, and long-term economic loss.
Largest patient-created national-security health-risk model
Mapping population-level illness burden, force-readiness instability, infrastructure strain, and emergency response vulnerability.
Largest rural pediatric chronic illness risk architecture
Integrating environmental exposure, economic fragility, hospital scarcity, and developmental instability across rural regions.
Largest environmental illness flare-prediction system in the U.S.
VitalGuard™ provides national-scale flare forecasting tied to climate volatility.
Women’s Health Firsts
First multi-phase women’s immune–endocrine modeling architecture
A unified system covering puberty, menstrual-phase physiology, pregnancy, postpartum instability, perimenopause, and menopause across multisystem chronic illness terrain.
First female-immune phenotyping system in remission modeling
Connects hormonal signaling, autonomic drift, vascular instability, and multi-organ inflammation into actionable remission windows.
First end-to-end maternal health engine built outside federal agencies
Models pregnancy-linked immune vulnerability, labor recovery physiology, autonomic collapse risk, and chronic postpartum terrain.
First women’s health engine scaling 10⁸⁰ analytic architecture
The only women’s health model operating inside a system exceeding 10⁸⁰ non-redundant pathways.
First system for women’s hormones, pediatrics and household stability
A cross-generational model capturing how maternal endocrine, immune, and autonomic states influence child health risk, neonatal immune drift, and family-system vulnerability.
First environmental–hormone engine for chronic illness in women
Integrates barometric pressure, humidity, wildfire smoke, mold exposure, and chemical triggers with menstrual and perimenopausal physiology.
Pediatric Health Firsts
First nationwide pediatric IACC modeling ecosystem
A complete architecture covering PANS, PANDAS, MIS-C, pediatric ME/CFS, viral-onset dysautonomia, immune–endocrine maturation, school-performance decline, and developmental regression.
First pediatric endocrine–immune drift architecture
Captures puberty-triggered immune instability and autonomic collapse risk across chronic illness trajectories.
First school-linked chronic illness performance engine
Bridges illness severity, autonomic dysfunction, cognitive drift, absenteeism, and academic remediation planning.
First pediatric chronic-illness engine embedded in a 10⁸⁰ scale model
The only children’s health system operating within an analytic structure exceeding 10⁸⁰ pathways.
First rural-environmental pediatric risk engine
Links rural hospital scarcity, agricultural exposures, mold proliferation, climate volatility, and economic instability to pediatric flare risk and developmental derailment.
First pediatric digital-twin system capable of scaling 1 billion trajectories
A multisystem synthetic-youth model covering autonomic development, immune drift, cognitive change, and environmental sensitivity over time.
About the Founder
Cynthia Adinig is a researcher, health policy advisor, author, and patient advocate. She is the founder of CYNAERA and creator of the patent-pending Bioadaptive Systems Therapeutics (BST)™ platform. She serves as a PCORI Merit Reviewer, Board Member at Solve M.E., and collaborator with Selin Lab for t cell research at the University of Massachusetts.
Cynthia has co-authored research with Harlan Krumholz, MD, Dr. Akiko Iwasaki, and Dr. David Putrino, though Yale’s LISTEN Study, advised Amy Proal, PhD’s research group at Mount Sinai through its patient advisory board, and worked with Dr. Peter Rowe of Johns Hopkins on national education and outreach focused on post-viral and autonomic illness. She has also authored a Milken Institute essay on AI and healthcare, testified before Congress, and worked with congressional offices on multiple legislative initiatives. Cynthia has led national advocacy teams on Capitol Hill and continues to advise on chronic-illness policy and data-modernization efforts.
Cynthia’s work with complex chronic conditions is deeply informed by her lived experience surviving the first wave of the pandemic, which strengthened her dedication to reforming how chronic conditions are understood, studied, and treated. She is also an advocate for domestic-violence prevention and patient safety, bringing a trauma-informed perspective to her research and policy initiatives.