The Human Variable 

Climate change is accelerating fungal evolution at the same moment millions of Americans are living with post-COVID immune instability. This white paper introduces CYNAERA’s national fungal-intelligence architecture, integrating climate analytics, immune-terrain modeling, wastewater genomics, micro-clinic stabilization, and antifungal combination logic. It explains why fungal threats are rising, how existing federal infrastructure can be repurposed immediately and what the Un

When the full IACC population is included, the national total of adults likely experiencing medical sabotage, partner interference, or care-linked neglect rises to approximately 24 million. RAVYNS™ is the first integrated system to transform partner interference and institutional neglect in chronic-illness care into an auditable public-health metric.

By October 2025, CYNAERA’s federal-scale models identified between $1.05 trillion and $3.45 trillion in potential annual savings for the United States through modular frameworks that stabilize health, accelerate remission, and optimize budgetary flow across SSA, CMS, VA, and FEMA

The COVID-19 pandemic has added another layer of immune instability through persistent inflammation, viral reactivations, and population-wide biologic stress . CRATE™ converts these complex dynamics into actionable modeling signals to inform future prevention strategy

Introduction Myalgic encephalomyelitis/chronic fatigue syndrome is common, costly, and routinely missed until someone reads the chart as a timeline. Patients describe a delayed crash after effort that lasts days to weeks. CDC and NICE name this pattern post-exertional malaise and make it central to diagnosis (CDC, 2024; NICE NG206, 2021). Yet most people with ME/CFS still do not have a diagnosis, and many wait years for recognition, with the National Academies reporting both

Innovative Orthostatic Intolerance & POTS Detection for Faster Diagnosis. Orthostatic intolerance and POTS are increasingly more common, disabling, and often missed until someone reads the chart as a timeline. The signs of these conditions already lives in routine positions and vitals clinicians collect anyway: triage after upright waiting, first supine on the bed, a short bathroom walk and return, and discharge.