The Human Variable 

The CYNAERA Primary Chronic Trigger (PCT) framework embeds PEM as a probability-weighted conversion event inside a prevalence model that accounts for viral exposure, environmental load, climate volatility, and recovery suppression. Modeled remission rises from historical 12–18 percent toward 35–50 percent under PEM-aware, terrain-timed designs, with early-intervention subsets reaching 42–60 percent in best-case conditions.

This white paper argues that MCS and MCAS are vantage points on a shared hypersensitivity terrain, proposing a new classification, Multi-Chemical and Environmental Hypersensitivity Disorders (MCEHD), that unites them, honors patient ingenuity, and formalizes my frameworks.

The CYNAERA ESA (Emergency Stabilization Authorization) framework presents a solution. During a declared emergency, ESA enables states and FEMA to pre-authorize qualified clinics to operate as temporary micro-ERs and reimburse those services as emergency protective measures. Critically, ESA does not require new legislation. It strategically aligns existing authorities under the Stafford Act for federal disaster declarations, FEMA Public Assistance Category B for emergency pro

 After adjusting for significant comorbidity and overlap, we estimate that 65–75 million unique individuals in the United States live with one or more IACCs. This includes approximately 20–25 million individuals with multiple co-occurring conditions. The revised estimates reveal a dramatic undercount across all conditions, particularly for post-viral and neuroimmune syndromes.

Using a multi-model estimation approach, we project that 8–12 million Americans may be experiencing chronic health impacts following vaccination, with 40–50 percent facing functional disability. The associated annual economic burden ranges from $100 to $500 billion. We propose that the adoption of immune-informed readiness protocols could prevent up to 1.6 million cases annually, saving $20–40 billion per year.

The CYNAERA ME/CFS Individualized Regimen Engine™ is an educational modeling framework that simulates phased strategies for ME/CFS care. Built on CYNAERA’s ecosystem of validated modules — including Treatment Archetypes, Phenotyping Framework, Pathophysiology Drivers, and the Path of Remission Model — the Regimen Engine demonstrates how individualized patient care can be systematically structured.