CYNAERA U.S. Chronic Condition Prevalence Database™
The Largest U.S. Chronic Condition Prevalence Database
Explore the most extensive collection of chronic condition prevalence research developed by CYNAERA Institute, covering more than 2,000 condition records across 20 medical specialty categories. Discover U.S. prevalence estimates, demographic-specific statistics, and research revealing where conventional disease reporting may underestimate the full extent of chronic illness. Explore combined condition prevalence by medical specialty and access downloadable research collections.
Using CYNAERA's proprietary U.S. Chronic Condition Undercount Correction (US-CCUC™) methodology, the database brings together condition-specific modeling across established medical specialties and emerging areas of chronic disease research. The collection includes research on infection-associated chronic conditions, autoimmune diseases, neurological disorders, cardiovascular conditions, women's health, environmental illnesses, and other complex medical conditions. Particular attention is given to conditions that may be inadequately represented in conventional surveillance, administrative datasets, or published prevalence estimates.
2000+ modeled condition records | 20 research categories | U.S. demographic prevalence
Explore Chronic Condition Prevalence Across 20 Medical Specialties
The CYNAERA U.S. Chronic Condition Prevalence Database™ organizes over 2,000 research records into 20 medical specialty collections, providing one of the broadest resources for exploring chronic condition prevalence and potential diagnostic undercounting in the United States. Each specialty collection examines conditions within its medical field, including demographic-specific prevalence patterns, overlapping phenotypes, and populations that may be underrepresented in conventional health statistics. Browse the categories below to explore combined U.S. condition prevalence estimates and access downloadable research publications.
Select a research category below to review its summary, combined U.S. condition prevalence estimate, and downloadable PDF collection.
1. Infectious and Post-Infectious Conditions
2. Autoimmune Conditions and Immunology
3. Neurology and Neurological Disorders
4. Neuroimmunology and Neuroinflammation
5. Cardiovascular and Autonomic Medicine
6. Pulmonology and Respiratory Medicine
7. Gastroenterology and Hepatology
8. Endocrinology and Metabolic Disorders
9. Rheumatology and Musculoskeletal Disorders
10. Allergy, Immunology, and Mast Cell Disorders
11. Dermatology and Skin Disorders
12. Gynecology and Reproductive Health
13. Maternal Health and Postpartum Conditions
14. Pediatrics and Adolescent Medicine
15. Oncology and Cancer-Related Conditions
16. Nephrology, Urology, and Hematology
17. Otolaryngology and Upper Airway Medicine
18. Dentistry and Oral Health
19. Environmental and Occupational Health
20. Aerospace and Space Medicine
Research developed by Cynthia Adinig, CYNAERA Institute.
Infectious and Post-Infectious Conditions
Research examining Long COVID, ME/CFS, Lyme disease, post-treatment Lyme disease syndrome (PTLDS), post-viral illness, and chronic complications following bacterial, viral, and vector-borne infections. The collection explores U.S. prevalence, persistent symptoms, diagnostic undercounting, and demographic differences in infection-associated chronic conditions.
Autoimmune Diseases and Immunology
Research covering systemic lupus erythematosus (SLE), Sjögren's disease, autoimmune thyroid conditions, and other immune-mediated disorders. The collection examines U.S. prevalence estimates, diagnostic delays, inflammatory complications, and demographic differences in autoimmune disease burden.
Neurology and Neurological Disorders
Research examining peripheral neuropathy, small fiber neuropathy, migraine, vestibular disorders, cognitive impairment, and chronic neurological complications associated with systemic illness. Studies address U.S. neurological disease prevalence, underdiagnosis, and demographic-specific patterns.
Neuroimmunology and Neuroinflammation
Research investigating neuroinflammatory disorders, immune-mediated neurological dysfunction, post-infectious neuroimmune conditions, and chronic interactions between the immune and nervous systems. The collection explores U.S. prevalence estimates, overlapping neurological symptoms, and potential diagnostic undercounting.
Cardiovascular and Autonomic Medicine
Research covering postural orthostatic tachycardia syndrome (POTS), dysautonomia, orthostatic intolerance, autonomic neuropathy, heart rhythm disorders, and vascular regulation abnormalities. The collection examines U.S. cardiovascular and autonomic condition prevalence, diagnostic gaps, and demographic-specific disease patterns.
Pulmonology and Respiratory Medicine
52 Research Records
Research examining asthma, chronic respiratory inflammation, post-infectious pulmonary conditions, persistent cough, and respiratory dysfunction associated with systemic and environmental illness. The collection investigates U.S. respiratory disease prevalence, exposure-related complications, and diagnostic undercounting.
Pulmonology and Respiratory Medicine
Research examining asthma, chronic respiratory inflammation, post-infectious pulmonary conditions, persistent cough, and respiratory dysfunction associated with systemic and environmental illness. The collection investigates U.S. respiratory disease prevalence, exposure-related complications, and diagnostic undercounting.
Gastroenterology and Hepatology
Research covering irritable bowel syndrome (IBS), gastrointestinal dysmotility, gastroparesis, eosinophilic esophagitis, inflammatory digestive conditions, and chronic liver and pancreatic disorders. Studies investigate U.S. digestive disease prevalence, demographic differences, and underrecognized gastrointestinal complications.
Endocrinology and Metabolic Disorders
Research examining thyroid disorders, diabetes-related complications, hormonal dysregulation, metabolic dysfunction, mitochondrial disorders, and chronic endocrine conditions. The collection explores U.S. endocrine disease prevalence, demographic-specific patterns, and potential gaps in diagnosis and population surveillance.
Rheumatology and Musculoskeletal Disorders
Research covering inflammatory arthritis, reactive arthritis, connective tissue disorders, chronic musculoskeletal pain, fibromyalgia-associated presentations, and rheumatologic complications of systemic illness. Studies examine U.S. prevalence estimates, delayed diagnosis, and demographic differences in musculoskeletal disease burden.
Allergy, Immunology, and Mast Cell Disorders
Research examining mast cell activation syndrome (MCAS), chronic urticaria, allergic inflammatory disorders, hypersensitivity conditions, and multisystem immune dysregulation. The collection investigates U.S. prevalence estimates, overlapping clinical presentations, and potential underdiagnosis of complex allergic and mast cell conditions.
Dermatology and Skin Disorders
Research examining eczema, chronic dermatitis, inflammatory skin conditions, immune-mediated dermatologic diseases, cutaneous vascular disorders, and persistent dermatologic complications. Studies explore U.S. skin disease prevalence, environmental and immune-related influences, and demographic differences in chronic dermatologic conditions.
Gynecology and Reproductive Health
Research covering endometriosis, polycystic ovary syndrome (PCOS), premenstrual dysphoric disorder (PMDD), menstrual disorders, reproductive hormone dysfunction, and chronic gynecologic conditions. The collection examines U.S. prevalence estimates, diagnostic delays, and demographic disparities in reproductive health.
Maternal Health and Postpartum Conditions
Research examining pregnancy-related complications, maternal immune dysfunction, postpartum illness, pregnancy-associated cardiovascular and metabolic conditions, and persistent health complications following childbirth. Studies investigate U.S. maternal health prevalence, demographic differences, and gaps in pregnancy and postpartum surveillance.
Pediatrics and Adolescent Medicine
Research covering pediatric chronic illness, PANS/PANDAS, childhood dysautonomia, pediatric post-infectious syndromes, immune-related disorders, and chronic conditions affecting adolescents. The collection examines U.S. pediatric prevalence estimates, age-specific disease patterns, diagnostic delays, and underrecognized childhood illness.
Oncology and Cancer-Related Conditions
Research examining cancer-related conditions, chemotherapy complications, cancer survivorship, treatment-associated immune dysfunction, radiation-related complications, and chronic neurological, metabolic, and autonomic conditions associated with oncology. The collection investigates U.S. cancer-related disease prevalence, long-term treatment effects, and demographic differences in disease burden.
Nephrology, Urology, and Hematology
Research covering sickle cell disease, chronic kidney disease, hematologic disorders, urinary system conditions, vascular complications, and immune-mediated renal disease. Studies examine U.S. prevalence estimates, chronic organ complications, demographic differences, and diagnostic undercounting across kidney, urinary, and blood disorders.
Otolaryngology and Upper Airway Medicine
Research examining chronic sinusitis, chronic rhinosinusitis, tinnitus, vestibular disorders, upper airway inflammation, and persistent ear, nose, and throat conditions. The collection explores U.S. ENT disease prevalence, chronic respiratory and neurological overlap, and diagnostic gaps affecting patients with persistent upper airway symptoms.
Dentistry and Oral Health
Research covering periodontal disease, chronic oral inflammation, temporomandibular joint (TMJ) disorders, dental complications, oral microbiome disturbances, and relationships between oral and systemic health. Studies investigate U.S. oral disease prevalence, chronic dental conditions, and demographic differences in oral health burden.
Environmental and Occupational Health
Research examining mold-associated illness, chemical sensitivity, indoor air pollution, wildfire smoke exposure, occupational respiratory conditions, and chronic health complications associated with environmental hazards. The collection investigates U.S. prevalence estimates, geographic exposure differences, and potential under-recognition of environmentally associated chronic illness.
Aerospace and Space Medicine
Research exploring aerospace-relevant conditions involving microgravity, altitude, hypoxia, circadian disruption, radiation exposure, autonomic dysfunction, and physiological responses to extreme environments. The collection examines chronic health conditions and biological adaptations relevant to aviation, spaceflight, and aerospace medicine, including population-specific prevalence where available.
Research developed by Cynthia Adinig, CYNAERA Institute.
Understanding Combined Condition Prevalence
Combined condition prevalence represents the sum of the individual condition-level prevalence estimates included within a research category. Because individuals may experience multiple conditions, these combined estimates should not be interpreted as counts of unique people.
All figures are identified as CYNAERA modeled research estimates rather than directly observed surveillance counts. Estimates may vary by reference year, population definition, available evidence, and modeling assumptions. Detailed methods, sources, and condition-specific information are provided in the corresponding research publications.
About the US-CCUC™ Methodology
The U.S. Chronic Condition Undercount Correction (US-CCUC™) methodology is a proprietary research framework developed by CYNAERA to investigate potential differences between conventionally reported disease prevalence and modeled population burden. The framework examines factors relevant to diagnostic recognition and population representation, including delayed diagnosis, potential misclassification, incomplete surveillance coverage, and demographic variation. The research is intended to support epidemiological investigation, health policy development, clinical research planning, and improved understanding of chronic condition prevalence. Individual estimates should be evaluated in relation to their supporting evidence, assumptions, and uncertainty.
Research Access, Citation, and Licensing
The CYNAERA U.S. Chronic Condition Prevalence Database™ provides publicly accessible research summaries and downloadable publications intended to support research discovery, scholarly citation, and informed public discussion. Researchers, academic institutions, healthcare organizations, government agencies, and commercial partners may inquire about specialty-specific datasets, demographic modeling, independent validation, customized research, and licensing of CYNAERA's proprietary analytical frameworks.
Public access to research publications does not grant a license to reproduce proprietary modeling systems, redistribute underlying datasets, or commercially incorporate CYNAERA intellectual property beyond applicable permissions and law.
For research collaborations, institutional access, or licensing inquiries, contact CYNAERA here.